团队队伍

胡文辉，男，博士生导师，广东省“珠江学者”特聘教授，药物化学学科带头人，广州市蛇毒与生物毒素研究所所长，兼伟德bv国际体育学术委员会主任，广东省分子靶标与临床药理重点实验室副主任，呼吸病国家重点实验室研究员。

胡教授于2002年毕业于中国协和医科大学药物研究所，师从郭宗儒教授，开展抗炎药物的研究，获得博士学位。2002年-2006年在美国西北大学医公司从事博士后研究，开展神经退行性疾病的药物研究。2006年-2016年在中国科公司广州生物医药与健康研究院历任副研究员、研究员、新药开发室主任。

立足于尚无有效药物的重大疾病，胡文辉课题开展创新药物的研究，建立了国内具有特色和优势的新药研发团队。在历时20多年的新药研究中,胡教授团队已确立多个全新结构的候选药物。其中，基于神经胶质细胞功能障碍的抗阿尔茨海默氏症新药AD16（哌达甲酮），已获得国家食品药品监督管理局（CFDA）颁发的1.1类药物临床试验批件，正在开展临床试验中，化合物专利涵盖了全球多个国家。截至目前，已发表了30多篇国际学术论文，申请了30多项国家、国际发明专利，兼任药学学报的编委、广东省药学会药物化学专业委员会副主委。

【联系邮箱】huwenhui@gzhmu.edu.cn

【研究方向】 创新药物研究

【主要科研项目】

截至目前，胡教授已主持国家科技部、国家自然科学基金委、广东省科技厅的新药重大专项，企业横向经费等各类新药基金近20项，金额逾2000多万元。目前的在研课题：国家自然科学基金面上项目，81872743，神经胶质细胞调节剂AD110延缓阿尔茨海默氏症的作用及机制研究。

【所获荣誉和奖励】2011年获得广东省优秀共产党员，2014年获得广东省优秀专利奖， 2018年获“珠江学者”特聘教授，2020年获广东省科技进步一等奖（第二负责人）。

【主要论文及著作（代表性）】

1. Ping Sun, Hu Yue, Qi Xing, Wenming Deng, Yitao Ou, Guangjin Pan, Xiaofen Zhong*, Wenhui Hu*. Compound AD16 reduces amyloid plaque deposition and modifies microglia in a transgenic mouse model of Alzheimer's disease. ACS Pharmacology & Translational Science. 2020. (In Press).

2. Jianghong Dong, Mengjie Xiao, Qinge Ma, Guicheng Zhang, Weijie Zhao,  Mengjie Kong, Yue Zhang, Luyun Qia, Wenhui Hu*. Design and synthesis of pinane oxime derivatives as novel anti-influenza agents. Bioorganic Chemistry. 2020, 102, 104106-104106.

3. Nannan Wu, Guangyu Lian, Jingyi Sheng, Dan Wu, Huiyao Lan, Wenhui Hu*, Zhongjin Yang*. Discovery of a Novel Selective Water-Soluble SMAD3 Inhibitor as an Antitumor Agent. Bioorganic Medicinal Chemistry letter. 2020, 30 (17), 127396.

4. Yitao Ou, Ping Sun, NanNan Wu, Hao Chen, Wenhui Hu*, Zhongjin Yang*. Synthesis and biological evaluation of parthenolide derivatives as potential inhibitors of the NLRP3 inflammasome. Bioorganic Medinal Chemistry letter. 2020, 30 (17), 127399.

5. Ping Sun, Wei Zhou, Hu Yue, Cheng Zhang, Yitao Ou, Zhongjin Yang^*, Wenhui Hu^*. Compound AD110 Acts as Therapeutic Management for Alzheimer’s Disease and Stroke in Mouse and Rat Models.  ACS Chemical Neuroscience, 2020, 11 (6), 929-938.

6. Wenmin Deng , Zhongjin Yang, Hu Yue, Yitao Ou, Wenhui Hu^*, Ping Sun^*. Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation. Free Radical Biology and Medicine, 2020, 152, 8-17.

7. Xin Zhao, Runfeng Li, Yang Zhou, Mengjie Xiao, Chunlong Ma, Zhongjin Yang, Shaogao Zeng, Qiuling Du, Chunguang Yang, Haiming Jiang, Yanmei Hu, Ping Sun, Jianghong Dong, Wei Cui, Kefeng Wang, Jun Wang, Yaoquan Tu, Zifeng Yang, Wenhui Hu*. Discovery of Highly Potent Pinanamine-Based Inhibitors Against Amantadine- and Oseltamivir-resistant Influenza A Viruses. Journal of Medicinal Chemistry. 2018, 61, 5187−5198.

8. Zhengtu Li, Junling Zhao, Hongxia Zhou, Li Li, Yuyang Ding, Jing Li, Beixian Zhou,Haiming Jiang, Nanshan Zhonga, Wenhui Hu*, Zifeng Yang*. Cappariloside A shows antiviral and better anti-inflammatory effects against influenza virus via regulating host IFN signaling, in vitro and vivo. Life Sciences 200 (2018) 115–125.

9. Hui Xie, Shaogao Zeng, Yuwen He, Guicheng Zhang, Pengjiu Yu, Guifa Zhong, Hongjiang Xu, Ling Yang, Shanchun Wang, Xin Zhao*, Wenhui Hu*. Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation. European Journal of Medicinal Chemistry, 2017, 141, 519-529.

10. Runfeng Li, Chunguang Yang, Qiuling Du, Xin Zhao, Haiming Jiang, Wenhui Hu*, Zifeng Yang*. Pinanamine Is a Promising Lead Compound against Influenza A Virus: Evidence from in Vitro and in Vivo Efficacy Compared to Amantadine. Biol. Pharm. Bull. 2017, 40, 954–959.

11. Yunlong Zhao, Qingxin Zhao, LS Wang, Wen Hui Hu*, Jun Ling Zhao*. Organocatalytic Friedel-Crafts Alkylation /Lactonization Reaction of Naphthols with 3-Trifluoroethylidene Oxindoles: The Asymmetric Synthesis of Dihydrocoumarins. Angewandte Chemie International Edition. 2017, 56, 338 –342.

12. Wei Zhou, Guifa Zhong, Sihai Fu, Hui Xie, Tianyan Chi, Luyi Li, Xiurong Rao，Shaogao Zeng, Dengfeng Xu, Hao Wang, Guoqing Sheng, Xing Ji, Xiaorong Liu, Xuefei Ji, Donghai Wu, Libo Zou, Micky Tortorella, Kejian Zhang, and Wenhui Hu*. Microglia-based phenotypic screening identifies a novel inhibitor of neuroinflammation effective in Alzheimer's Disease Models. ACS Chemical Neuroscience. 2016, Nov 16; 7 (11):1499-1507.

13. Jianghong Dong, Shengwei Chen, Runfeng Li, Wei Cui, Haiming Jiang, Yixia Ling, Zifeng Yang, Wenhui Hu*. Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus. European Journal of Medicinal Chemistry. 2016, 108, 605-615.

14. Shengwei Chen, Qinxin Lou, Yuyang Ding, Shasha Zhang, Wenhui Hu* and Junling Zhao* Organocatalytic enantioselective Michael reaction of malononitrile to b,b-disubstituted nitroalkenes. Advanced Synthesis & Catalysis. 2015, 357, 2437-2441. (Front Cover and Very Important Publication).

15. Shengwei Chen, Guicheng Zhang, Qxinxin Lou, Wei Cui, Shasha Zhang, Wenhui Hu* and Junling Zhao*. Organocatalytic enantioselective aza-Michael reaction of benzotriazole to β,β-disubstituted nitroalkenes. ChemCatChem. 2015, 7, 1935-1938. (Inside Back Cover).

16. Yuyang Ding, Liufeng Mao, Dengfeng Xu, Hui Xie, Ling Yang, Hongjiang Xu, Wenjun Geng, Yong Gao, Chunguang Xia, Xiquan Zhang, Qingyi Meng, Donghai Wu, Junling Zhao * and Wenhui Hu*. C-aryl glucoside SGLT2 inhibitors containing a biphenyl motif as potential anti-diabetic agents. Bioorganic Medinal Chemistry letter. 2015, 25, 2744-2748.

17. Bo Bi, Qin-Xin Lou, Yu-Yang Ding, Sheng-Wei Chen, Sha-Sha Zhang, Wen-Hui Hu* and Jun-Ling Zhao* Chiral phosphoric acid-catalyzed highly enantioselective Friedel-Crafts alkylation reaction of C3-substituted indoles to unsaturated ketimino esters. Organic Letters, 2015, 17, 540−543.

18. Xin Zhao*, ZhenWei Zhang, Wei Cui, Shengwei Chen, Yang Zhou,Jianghong Dong, Yanling Jie, Junting Wan, Yong Xu* and Wenhui Hu*. Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus. MedChemComm. 2015, 6, 727–731.